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- "A fully differentiated basophil, a granular leukocyte with an irregularly shaped, pale-staining nucleus that is partially constricted into two lobes, and with cytoplasm that contains coarse granules of variable size. Basophils contain vasoactive amines such as histamine and serotonin, which are released on appropriate stimulation."
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{- "prefLabel": "ameloblast",
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{- "prefLabel": "mast cell",
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"synonym": [- "histaminocyte",
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- "mastocyte",
- "tissue basophil"
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"definition": [- "Mast cells are generally integrin beta-7-negative and positive for TLR2, TLR3, TLR4, TLR5, TLR7, TLR9, C3aR, C5aR, CR3, CR4, VEGF, FGF2, and renin. They can express MHC Class I and II on their surface. Activated murine mast cells (IgE+Antigen) were capable of expressing the following co-stimulatory molecules: CD95 (Fas), CD120b, CD137 (4-1BB), CD153 (CD30L), CD154 (CD40L), GITR, ICOSL, OX40L, PD-L1, and PD-L2. Note that there was some mouse strain variation. Mast cells have also been demonstrated to produce bFGF, CCL2, CCL4, CCL5, CCL11, CCL20, CXCL2, CXCL8, CXCL10, GM-CSF, IFN-gamma, IL-1, IL-2, IL-3, IL-8, IL-10, IL-11, IL-12, IL-13, IL-16, IL-25, IL-18, MIP-1, prostaglandin D2, SCF, TGF-beta, TNF-alpha, TSLP, VEGF, and XCL1. They express the transcription factors Transcription factors AP-1, GATA1, MITF, Notch2, PIAS3, PU.1, and STAT5.",
- "A cell that is found in almost all tissues containing numerous basophilic granules and capable of releasing large amounts of histamine and heparin upon activation. Progenitors leave bone marrow and mature in connective and mucosal tissue. Mature mast cells are found in all tissues, except the bloodstream. Their phenotype is CD117-high, CD123-negative, CD193-positive, CD200R3-positive, and FceRI-high. Stem-cell factor (KIT-ligand; SCF) is the main controlling signal of their survival and development."
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{- "prefLabel": "club cell",
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{- "prefLabel": "parietal cell",
-
"synonym": [- "gastric parietal cell",
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"definition": [- "Parietal cells have dynamic, actin-supported microvilli that increase in number during active secretion, playing a crucial role in secreting hydrochloric acid and intrinsic factor. The structure and regulation of these microvilli are influenced by proteins such as ASAP3, which modulates Arf6 activity and actin assembly, thereby controlling microvilli formation and parietal cell function.",
- "An epithelial cell of the stomach that is part of the fundic gastric gland. This cell is characterized by its pyramidal shape, abundant mitochondria, and a complex network of secretory canaliculi lined with microvilli. It secretes hydrochloric acid into the stomach lumen and produces intrinsic factor, essential for vitamin B12 absorption."
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},-
{- "prefLabel": "Leydig cell",
-
"synonym": [- "interstitial cell of Leydig",
- "interstitial cell"
],-
"definition": [- "Note that the Amphibian Anatomy Ontology (AA) has a class 'leydig cells' but this is unrelated",
- "A Leydig cell is a testosterone-secreting cell in the interstitial area, between the seminiferous tubules, in the testis."
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}
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{- "prefLabel": "Sertoli cell",
- "synonym": [ ],
-
"definition": [- "A supporting cell projecting inward from the basement membrane of seminiferous tubules. They surround and nourish the developing male germ cells and secrete androgen binding protein. Their tight junctions with the spermatogonia and spermatocytes provide a blood-testis barrier."
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},-
{- "prefLabel": "platelet",
-
"synonym": [- "anucleate thrombocyte",
- "blood platelet",
- "enucleate thrombocyte"
],-
"definition": [- "Platelets are reportedly CCR1-positive, CCR2-negative, CCR3-positive, CCR4-positive, CCR5-negative, CCR6-negative, CCR7-negative, CCR8-negative, CCR9-negative, CCR10-negative, CD16-positive, CD23-positive, CD32-positive, CD40-positive, CD41-positive CD42-positive, CD61-positive, CD62P-positive, CD64-positive, CD89-positive, CD102-positive, CD147-positive (activated platelets), CD154-positive (activated platelets), CD162-positive, CD209, CD282-positive, CD284-positive, CD289-positive, CD181-negative, CD182-negative, CD183-negative, CD184-positive, CLEC2-positive, GPVI-positive, JAMC-positive, PAR1-positive, PAR2-negative, PAR3-positive, PAR4-positive, TSP1-positive, and TXA2R-positive. Platelets can reportedly produce CCL2, CCL3, CCL5, CCL7, CCL17, CD40L, CXCL1, CXCL4, CXCL4L1, CXCL5, CXCL7, CXCL8, CXCL12, EGF, factor V, factor VII, factor XI, factor XIII, bFGF, histamine, IGF-1, IL-1beta, PAI-1, PDGF, plasminogen, protein S, serotonin, TGF-beta, TFPI, VEGF, and vWF.",
- "A non-nucleated disk-shaped cell formed by extrusion from megakaryocytes, found in the blood of all mammals, and mainly involved in blood coagulation."
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}
},-
{- "prefLabel": "granulosa cell",
-
"synonym": [- "granulosa cell of ovary"
],-
"definition": [- "A supporting cell for the developing female gamete in the ovary of mammals. They develop from the coelomic epithelial cells of the gonadal ridge. Granulosa cells form a single layer around the mammalian oocyte in the primordial ovarian follicle and advance to form a multilayered cumulus oophorus surrounding the ovum in the Graafian follicle. The major functions of granulosa cells include the production of steroids and LH receptors."
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{- "prefLabel": "paneth cell",
- "synonym": [ ],
-
"definition": [- "An epithelial cell found in the basal part of the intestinal glands (crypts of Lieberkuhn) including the appendix. Paneth cells synthesize and secrete lysozyme and cryptdins. Numerous in the deeper parts of the intestinal crypts, particularly in the duodenum, rich in zinc, contain large acidophilic granules, with irregular apical microvilli and prominent membrane-bound vacuoles containing matrix."
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- "mappings": "http://data.bioontology.org/metadata/Mapping",
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"@context": {- "@vocab": "http://data.bioontology.org/metadata/",
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- "synonym": "http://www.w3.org/2004/02/skos/core#altLabel",
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}
},-
{- "prefLabel": "parafollicular cell",
-
"synonym": [- "C cell",
- "C cell of thyroid gland",
- "clear cell of thyroid gland",
- "parafollicular cell of thyroid gland",
- "thyroid parafollicular cell"
],-
"definition": [- "A neuroepithelial cells that occurs singly or in small groups, close to the outer follicular borders but within the follicular basement membrane of the thyroid. Expresses a form of the neural cell adhesion molecule (N-CAM) on their surface. Secretes calcitonin, 5-hydroxytryptamine and dopamine."
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"@context": {- "self": "http://www.w3.org/2002/07/owl#Class",
- "ontology": "http://data.bioontology.org/metadata/Ontology",
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- "created": "http://purl.org/dc/terms/created",
- "modified": "http://purl.org/dc/terms/modified",
- "@language": "en"
}
},-
{- "prefLabel": "GABAergic neuron",
-
"synonym": [],-
"definition": [- "A neuron that uses GABA as a vesicular neurotransmitter"
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"links": {- "self": "https://data.agroportal.lirmm.fr/ontologies/EFO/classes/http%3A%2F%2Fpurl.obolibrary.org%2Fobo%2FCL_0000617",
- "ontology": "https://data.agroportal.lirmm.fr/ontologies/EFO",
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"@context": {- "self": "http://www.w3.org/2002/07/owl#Class",
- "ontology": "http://data.bioontology.org/metadata/Ontology",
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- "ui": "http://www.w3.org/2002/07/owl#Class"
}
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"@context": {- "@vocab": "http://data.bioontology.org/metadata/",
- "prefLabel": "http://www.w3.org/2004/02/skos/core#prefLabel",
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- "modified": "http://purl.org/dc/terms/modified",
- "@language": "en"
}
},-
{- "prefLabel": "glutamatergic neuron",
- "synonym": [ ],
-
"definition": [- "A neuron that is capable of some neurotansmission by glutamate secretion."
],- "cui": [ ],
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"links": {- "self": "https://data.agroportal.lirmm.fr/ontologies/EFO/classes/http%3A%2F%2Fpurl.obolibrary.org%2Fobo%2FCL_0000679",
- "ontology": "https://data.agroportal.lirmm.fr/ontologies/EFO",
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"@context": {- "self": "http://www.w3.org/2002/07/owl#Class",
- "ontology": "http://data.bioontology.org/metadata/Ontology",
- "children": "http://www.w3.org/2002/07/owl#Class",
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- "notes": "http://data.bioontology.org/metadata/Note",
- "mappings": "http://data.bioontology.org/metadata/Mapping",
- "ui": "http://www.w3.org/2002/07/owl#Class"
}
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"@context": {- "@vocab": "http://data.bioontology.org/metadata/",
- "prefLabel": "http://www.w3.org/2004/02/skos/core#prefLabel",
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- "created": "http://purl.org/dc/terms/created",
- "modified": "http://purl.org/dc/terms/modified",
- "@language": "en"
}
},-
{- "prefLabel": "dopaminergic neuron",
-
"synonym": [],-
"definition": [- "A neuron that releases dopamine as a neurotransmitter."
],- "cui": [ ],
- "semanticType": [ ],
- "obsolete": false,
- "created": null,
- "modified": null,
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"links": {- "self": "https://data.agroportal.lirmm.fr/ontologies/EFO/classes/http%3A%2F%2Fpurl.obolibrary.org%2Fobo%2FCL_0000700",
- "ontology": "https://data.agroportal.lirmm.fr/ontologies/EFO",
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"@context": {- "self": "http://www.w3.org/2002/07/owl#Class",
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- "mappings": "http://data.bioontology.org/metadata/Mapping",
- "ui": "http://www.w3.org/2002/07/owl#Class"
}
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"@context": {- "@vocab": "http://data.bioontology.org/metadata/",
- "prefLabel": "http://www.w3.org/2004/02/skos/core#prefLabel",
- "synonym": "http://www.w3.org/2004/02/skos/core#altLabel",
- "definition": "http://www.w3.org/2004/02/skos/core#definition",
- "obsolete": "http://www.w3.org/2002/07/owl#deprecated",
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- "cui": "http://bioportal.bioontology.org/ontologies/umls/cui",
- "inScheme": "http://www.w3.org/2004/02/skos/core#inScheme",
- "created": "http://purl.org/dc/terms/created",
- "modified": "http://purl.org/dc/terms/modified",
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}
},-
{- "prefLabel": "pulmonary alveolar type 2 cell",
-
"synonym": [- "cuboidal type II cell",
- "granular pneumocyte",
- "great alveolar cell",
- "lung type 2 cell",
- "type 2 alveolar epithelial cell",
- "type 2 alveolocyte",
- "type 2 pneumocyte",
- "type II alveolar cell",
- "type II alveolar epithelial cell",
- "type II alveolocyte",
- "type II pneumocyte",
- "AT2",
- "ATII",
- "TII",
- "lung type II cell"
],-
"definition": [- "The marker set SFTPA1 can identify the Human cell type pulmonary alveolar type 2 cell in the Lung with a confidence of 0.95 (NS-Forest FBeta value).",
- "A pulmonary alveolar epithelial cell that modulates the fluid surrounding the alveolar epithelium by secreting and recycling surfactants. This cell type also contributes to tissue repair and can differentiate after injury into a pulmonary alveolar type 1 cell. This cuboidal cell is thicker than squamous alveolar cells, have a rounded apical surface that projects above the level of surrounding epithelium. The free surface is covered by short microvilli."
],- "cui": [ ],
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"links": {- "self": "https://data.agroportal.lirmm.fr/ontologies/EFO/classes/http%3A%2F%2Fpurl.obolibrary.org%2Fobo%2FCL_0002063",
- "ontology": "https://data.agroportal.lirmm.fr/ontologies/EFO",
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"@context": {- "self": "http://www.w3.org/2002/07/owl#Class",
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}
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"@context": {- "@vocab": "http://data.bioontology.org/metadata/",
- "prefLabel": "http://www.w3.org/2004/02/skos/core#prefLabel",
- "synonym": "http://www.w3.org/2004/02/skos/core#altLabel",
- "definition": "http://www.w3.org/2004/02/skos/core#definition",
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- "created": "http://purl.org/dc/terms/created",
- "modified": "http://purl.org/dc/terms/modified",
- "@language": "en"
}
},-
{- "prefLabel": "endocrine pancreas",
-
"synonym": [- "endocrine pancreas",
- "pars endocrina pancreatis",
- "endocrine part of pancreas",
- "islets of Langerhans part of pancreas"
],-
"definition": [- "The part of the pancreas that is part of the endocrine system and is made up of islet cells, which produce insulin, glucagon and somatostatin."
],- "cui": [ ],
- "semanticType": [ ],
- "obsolete": false,
- "created": null,
- "modified": null,
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- "@type": "http://www.w3.org/2002/07/owl#Class",
-
"links": {- "self": "https://data.agroportal.lirmm.fr/ontologies/EFO/classes/http%3A%2F%2Fpurl.obolibrary.org%2Fobo%2FUBERON_0000016",
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"synonym": [],-
"definition": [- "Skeletogenic cell that is terminally differentiated, secretes an avascular, GAG-rich matrix, is embedded in cartilage tissue matrix, retains the ability to divide, and develops from a chondroblast cell."
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{- "prefLabel": "endocrine cell",
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"synonym": [],-
"definition": [- "A cell of an endocrine gland, ductless glands that secrete substances which are released directly into the circulation and which influence metabolism and other body functions."
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{- "prefLabel": "acinar cell",
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"synonym": [- "acinic cell",
- "acinous cell"
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"definition": [- "A secretory cell that is grouped together with other cells of the same type to form grape shaped clusters known as acini (singular acinus)."
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}